Search Result
Results for "
aqueous solubility
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-151392
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Others
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Neurological Disease
Inflammation/Immunology
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LPA5 antagonist 2 (compound 65) is a high aqueous solubility LPA5 (lysophosphatidic acid receptor 5) antagonist. LPA5 antagonist 2 significantly attenuates nociceptive hypersensitivity and it can be used for the research of inflammatory and neuropathic pains .
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- HY-144287
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Glucokinase
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Endocrinology
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Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes .
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- HY-145261
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Dihydroorotate Dehydrogenase
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Inflammation/Immunology
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hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma .
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- HY-D1307A
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Fluorescent Dye
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Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.
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- HY-D1307
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Fluorescent Dye
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Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.
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- HY-126321
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ROR
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Cancer
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RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist with an EC50 of 20.8 nM. RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile. RORγt agonist 1 is a potential candidate of RORγt agonist for cancer immunotherapy .
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- HY-19323A
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(S)-AZD6738
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ATM/ATR
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Cancer
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(S)-Ceralasertib ((S)-AZD6738) is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM .
(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.
(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition .
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- HY-151134
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HBV
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Infection
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HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA>452 μg/mL) and good PK property with no cellular toxicity .
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- HY-152614
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Parasite
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Infection
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Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC50 values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine .
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- HY-W127790
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Biochemical Assay Reagents
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Others
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Bathophenanthrolinedisulfonic acid disodium salt is used as a colorimetric reagent for the detection of iron. It is widely used for the determination of iron in aqueous solutions without the use of extraction solvents. It is used as a precursor for the preparation of the anion Europium(III) disulfonated bathophenanthroline tris(dibenzoylformic acid) complex and ruthenium II tris(rubphenanthroline disulfonate). It plays a crucial role in the catalytic oxidation of 2-hexanol by enabling it to form a water-soluble complex with palladium.
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- HY-D2242
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Fluorescent Dye
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Others
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Sulfo-Cy7.5 DBCO is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing a DBCO group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Sulfo-Cy7.5 DBCO can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples .
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- HY-16643
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- HY-D1865
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Fluorescent Dye
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Others
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Cy3 dimethyl iodide is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) with a dimethyl group in the iodide salt form. The iodide salt form increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a near-infrared fluorescent dye commonly used in biolabeling and cell imaging. Cy3 dimethyl iodide binds to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1846
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Fluorescent Dye
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Others
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Sulfo-Cy7.5 dimethyl is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with a dimethyl group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. Sulfo-Cy7.5 dimethyl binds to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-W099581
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Zwittergent 3-14
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Biochemical Assay Reagents
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Others
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Zwittergent 3-14 (DMAPS) is a zwitterionic detergent commonly used in biochemistry and molecular biology for the solubilization and purification of membrane-bound proteins and other hydrophobic biomolecules, which have both hydrophilic and hydrophobic moieties , so that it has good detergency properties, making it suitable for stabilizing membrane proteins in aqueous solutions. In addition, DMAPS has been used in various techniques such as electrophoresis and chromatography for the separation and analysis of biomolecules. The long The hydrocarbon chains provide it with good membrane penetration and solubilization capabilities, while the sulfonate and quaternary ammonium groups ensure water solubility and charge neutrality.
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- HY-D1272
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Sulfo-Cyanine3 amine
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Fluorescent Dye
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Others
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Sulfo-Cy3 amine is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1375
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Fluorescent Dye
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Others
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Sulfo-Cy5 amine is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy5 is a near-infrared fluorescent dye commonly used in biolabeling and cell imaging. The amine functionality of Sulfo-Cy5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1864
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Fluorescent Dye
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Others
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Sulfo-Cy7.5 dicarboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 dicarboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
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- HY-D1861
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Fluorescent Dye
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Others
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Sulfo-Cy3 hydrazide is a Cyanine 3 (Cy3) (HY-D0822) dye derivative with hydrazine functionality. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The hydrazide group of Sulfo-Cy3 hydrazide can form hydrazinone coupling with molecules containing aldehydes or ketones to form covalent bonds. Therefore, Cy3 azide plus can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1866
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Fluorescent Dye
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Others
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Sulfo-Cy7.5 carboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate ion (sulfonate) functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 carboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
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- HY-D1863
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Fluorescent Dye
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Others
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sulfo-Cy7.5 amine is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The amine functionality of sulfo-Cy7.5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy7.5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1859
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Fluorescent Dye
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Others
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Sulfo-Cy7.5 alkyne is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) containing a sulfonate ion and an alkyne functional group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The alkyne functionality of Sulfo-Cy7.5 alkyne can react with molecules containing the azide functionality to form covalent bonds. Sulfo-Cy7.5 alkyne can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1850
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Fluorescent Dye
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Others
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Sulfo-Cy7.5 azide is a Cyanine 7.5 (Cy7.5) (HY-D0926) dye derivative with azide and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The azide group of Sulfo-Cy7.5 azide can react chemically with molecules containing alkyne functionality, such as alkyne or cyclooctyne, to form covalent bonds. Therefore, Sulfo-Cy7.5 azide can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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HY-L0115V
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10,091 compounds
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ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.
Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.
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HY-L0116V
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1,065 compounds
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Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.
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Cat. No. |
Product Name |
Type |
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- HY-D1307A
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Fluorescent Dyes/Probes
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Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.
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- HY-D1307
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Fluorescent Dyes/Probes
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Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.
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- HY-D2242
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Fluorescent Dyes/Probes
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Sulfo-Cy7.5 DBCO is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing a DBCO group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Sulfo-Cy7.5 DBCO can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples .
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- HY-D1865
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Fluorescent Dyes/Probes
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Cy3 dimethyl iodide is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) with a dimethyl group in the iodide salt form. The iodide salt form increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a near-infrared fluorescent dye commonly used in biolabeling and cell imaging. Cy3 dimethyl iodide binds to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1846
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Fluorescent Dyes/Probes
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Sulfo-Cy7.5 dimethyl is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with a dimethyl group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. Sulfo-Cy7.5 dimethyl binds to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1272
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Sulfo-Cyanine3 amine
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Fluorescent Dyes/Probes
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Sulfo-Cy3 amine is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The amine functionality of Sulfo-Cy3 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy3 amine can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1375
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Fluorescent Dyes/Probes
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Sulfo-Cy5 amine is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy5 is a near-infrared fluorescent dye commonly used in biolabeling and cell imaging. The amine functionality of Sulfo-Cy5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1864
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Fluorescent Dyes/Probes
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Sulfo-Cy7.5 dicarboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 dicarboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
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- HY-D1861
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Fluorescent Dyes/Probes
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Sulfo-Cy3 hydrazide is a Cyanine 3 (Cy3) (HY-D0822) dye derivative with hydrazine functionality. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The hydrazide group of Sulfo-Cy3 hydrazide can form hydrazinone coupling with molecules containing aldehydes or ketones to form covalent bonds. Therefore, Cy3 azide plus can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1866
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Fluorescent Dyes/Probes
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Sulfo-Cy7.5 carboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate ion (sulfonate) functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 carboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
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- HY-D1863
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Fluorescent Dyes/Probes
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sulfo-Cy7.5 amine is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing an amine group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The amine functionality of sulfo-Cy7.5 amine can react with carboxyl groups to form covalent bonds. Sulfo-Cy7.5 amine can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1859
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Fluorescent Dyes/Probes
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Sulfo-Cy7.5 alkyne is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) containing a sulfonate ion and an alkyne functional group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The alkyne functionality of Sulfo-Cy7.5 alkyne can react with molecules containing the azide functionality to form covalent bonds. Sulfo-Cy7.5 alkyne can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1850
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Fluorescent Dyes/Probes
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Sulfo-Cy7.5 azide is a Cyanine 7.5 (Cy7.5) (HY-D0926) dye derivative with azide and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The azide group of Sulfo-Cy7.5 azide can react chemically with molecules containing alkyne functionality, such as alkyne or cyclooctyne, to form covalent bonds. Therefore, Sulfo-Cy7.5 azide can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
|
Cat. No. |
Product Name |
Type |
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- HY-W099581
-
Zwittergent 3-14
|
Biochemical Assay Reagents
|
Zwittergent 3-14 (DMAPS) is a zwitterionic detergent commonly used in biochemistry and molecular biology for the solubilization and purification of membrane-bound proteins and other hydrophobic biomolecules, which have both hydrophilic and hydrophobic moieties , so that it has good detergency properties, making it suitable for stabilizing membrane proteins in aqueous solutions. In addition, DMAPS has been used in various techniques such as electrophoresis and chromatography for the separation and analysis of biomolecules. The long The hydrocarbon chains provide it with good membrane penetration and solubilization capabilities, while the sulfonate and quaternary ammonium groups ensure water solubility and charge neutrality.
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- HY-W127790
-
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Biochemical Assay Reagents
|
Bathophenanthrolinedisulfonic acid disodium salt is used as a colorimetric reagent for the detection of iron. It is widely used for the determination of iron in aqueous solutions without the use of extraction solvents. It is used as a precursor for the preparation of the anion Europium(III) disulfonated bathophenanthroline tris(dibenzoylformic acid) complex and ruthenium II tris(rubphenanthroline disulfonate). It plays a crucial role in the catalytic oxidation of 2-hexanol by enabling it to form a water-soluble complex with palladium.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P4389
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Peptides
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Metabolic Disease
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(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon .
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Cat. No. |
Product Name |
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Classification |
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- HY-D1307A
-
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Alkynes
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Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.
|
-
- HY-D1307
-
|
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Alkynes
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Sulfo-cyanine7 alkyne is a water-soluble near-infrared dye with a sulfonated terminal alkyne that can be used in copper-catalyzed click chemistry reactions to conjugate with azides in an aqueous environment.
|
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- HY-D2242
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|
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DBCO
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Sulfo-Cy7.5 DBCO is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) bearing a DBCO group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Sulfo-Cy7.5 DBCO can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples .
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- HY-D1859
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Alkynes
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Sulfo-Cy7.5 alkyne is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) containing a sulfonate ion and an alkyne functional group. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The alkyne functionality of Sulfo-Cy7.5 alkyne can react with molecules containing the azide functionality to form covalent bonds. Sulfo-Cy7.5 alkyne can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-D1850
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Azide
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Sulfo-Cy7.5 azide is a Cyanine 7.5 (Cy7.5) (HY-D0926) dye derivative with azide and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used for biolabeling and cell imaging. The azide group of Sulfo-Cy7.5 azide can react chemically with molecules containing alkyne functionality, such as alkyne or cyclooctyne, to form covalent bonds. Therefore, Sulfo-Cy7.5 azide can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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